|
KMID : 1137020100210040248
|
|
Journal of Gynecologic Oncology
2010 Volume.21 No. 4 p.248 ~ p.254
|
|
|
Comparison of total plasma lysophosphatidic acid and serum CA-125 as a tumor marker in the diagnosis and follow-up of patients with epithelial ovarian cancer
|
|
Bese Tugan
Barbaros Merve
Baykara Elif
Guralp Onur
Cengiz Salih
Demirkiran Fuat
Sanioglu Cevdet
Arvas Macit
|
|
|
Abstract
|
|
|
Objective: To evaluate the role of lysophosphatidic acid (LPA) as a tumor marker in diagnosis and follow-up of patients with epithelial ovarian cancer.
Methods: Eighty-seven epithelial ovarian cancer patients, 74 benign ovarian tumor patients, and 50 healthy women were enrolled in the study. Twenty-nine of 87 epithelial ovarian cancer patients were followed up for 6 cycles of paclitaxel-carboplatin chemotherapy. CA-125 and total plasma LPA levels were measured preoperatively and before each chemotherapy cycle.
Results: Preoperative total plasma LPA and serum CA-125 levels were significantly higher in patients with epithelial ovarian cancer compared to patients with benign ovarian tumors and healthy women. Cut-off value for LPA was determined as 1.3 ?mol/L and sensitivity, specificity, positive predictive value and negative predictive value were 95%, 92%, 95% and 92%, respectively. Mean total plasma LPA level of 29 patients who received chemotherapy was 7.21±6.63 ?mol/L preoperatively and 6.84±6.34 ?mol/L, 6.34±5.92 ?mol/L, 6.14±5.79 ?mol/L, 5.86±5.68 ?mol/L, 5.23±5.11 ?mol/L and 5.21±5.32 ?mol/L in measurements held just before the 1st, 2nd, 3rd, 4th, 5th and 6th chemotherapy cycles, respectively (ANOVA, p=0.832). Total plasma LPA levels decreased slightly with chemotherapy administration and there was a weak negative correlation (Spearman, rs=?0.151, p=0.034), compared to a significant negative correlation in CA-125 (Spearman, rs=?0.596, p＜0.001).
Conclusion: LPA is a better biomarker for diagnosis of epithelial ovarian cancer compared to CA-125. However, measurement of total plasma LPA levels during chemotherapy administration have no superiority to the serum CA-125 levels.
|
|
|
KEYWORD
|
|
|
Lysophosphatidic acid, CA-125, Epithelial ovarian cancer, Follow-up, Chemotherapy, Tumor marker
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|
|